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2009 analyzed the efficacy of low-dose propranolol, low-dose nortriptyline, and combined propranolol plus nortriptyline for migraine prophylaxis.
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in dietary administration studies in which mice and rats were treated with propranolol hydrochloride for up to 18 months at doses of up to 150 mg kg day, there was no evidence of drug-related tumorigenesis.
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in addition to blockade of adrenergic receptors, propranolol has very weak inhibitory effects on the norepinephrine transporter and or weakly stimulates norepinephrine release i.
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